MINNEAPOLIS/ST. PAUL (07/10/2025) — A University of Minnesota Medical School-led research team discovered that a cancer signaling pathway has previously unrecognized roles in retina and brain blood ...

Druggable phosphatases in cancer and immune cells, with examples of their corresponding drugs. Structures of allosteric inhibitors targeting PP2A, PRL3, DUSP1/6, and SHP2 in cancer cells (left).

Colorectal tumors that underwent somatic next-generation sequencing (NGS) for 154-168 genes in an in-house laboratory between 2015 and 2022 were retrospectively identified. Microsatellite instability ...

A recent study published in the journal Frontiers in Endocrinology investigated the role of the short-chain dehydrogenase/reductase 42E member 1 (SDR42E1) enzyme in regulating sterol metabolism and ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

JCO Precision Oncology Conversations features discussions with leading authors of JCO Precision Oncology articles, hosted by Dr. Abdul Rafeh Naqash. Join our experts in engaging conversations as they ...