The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...

In human cells, DNA carries chemical or "epigenetic" marks that decide how genes will be used in different tissues. Yet in a ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

It is well known that adding a mixture of four reprogramming molecules (Oct4, Sox2, Klf4 and c-Myc) also known as “Yamanaka factors” to cells can reset epigenetic marks to their original patterns.

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development ...

Abnormalities in the TME contribute to immunosuppression and dictate the outcome of various immunotherapeutic approaches. Reprogramming specific facets of the immune compartment, such as ...

In the bloodstream, microscopic particles called extracellular vesicles (EVs) constantly drift—tiny capsules released by our cells to carry messages, sometimes of healing, sometimes of harm. Among ...